Starting a Nurse Practitioner Practice in Pennsylvania: Every Question, Answered

September 11, 2026
By Prax Health Research & Editorial Team
start your own practice

Pennsylvania calls its nurse practitioners CRNPs (Certified Registered Nurse Practitioners), and it asks more of their paperwork than most states do. There are two agreements instead of one, and a collaborating physician backup requirement that most people have never heard of, which can trip up do-it-yourself filers. None of it blocks nurse practitioner practice ownership, you just need to understand the requirements.

Can a nurse practitioner own a practice in Pennsylvania?

Yes. Pennsylvania CRNPs, also known as NPs, own independent practices across the state, structured as nursing professional entities that the CRNP owns. What Pennsylvania regulates tightly is the clinical relationship. CRNPs diagnose and prescribe in collaboration with a physician under written agreements. Unlike some other states, that requirement does not go away with experience.

One Pennsylvania-specific caution on the entity itself. In Pennsylvania, a nursing corporation typically should be a PC or PLLC, but the state's rules about which entities can support which professions can be nuanced, and nursing doesn't fit the standard structure that works in other states. Getting the entity type right for a Pennsylvania nursing practice is a five-minute decision for someone who knows PA guidance and an expensive redo for someone who doesn't.

Why does Pennsylvania have two agreements?

PA has two separate agreements because it splits collaboration and prescribing into separate paperwork. The collaborative agreement is the written arrangement between you and a Pennsylvania-licensed physician covering availability, an emergency plan, referrals, and regular consultation and chart review. For prescribing, you'll also file a prescriptive authority agreement with the state licensing system, and that filing has its own requirements, including naming at least one substitute physician alongside your primary collaborator.

That substitute physician detail surprises almost everyone. Practically, it means you're lining up two physician relationships. Of course, the collaborating physicians don't own any part of your practice and don't have to work where you work, but the agreements have to be in place to practice independently. If you don't have collaborating physicians in your network, Prax can connect you with trusted partners who pair NPs with MDs.

Does the collaboration requirement ever go away?

For now, the collaboration requirement is here to stay. Unlike New York's 3,600-hour threshold or Massachusetts' two-year gate, Pennsylvania has no experience-based path to independent practice. Full practice authority bills do appear in Harrisburg, PA session after session, and one may eventually pass. Until then, plan the collaboration, and its monthly cost, as a permanent part of your operating model.

What does a Pennsylvania launch actually involve?

The right professional entity with compliant governing documents (operating agreement or bylaws), federal tax setup and a business bank account, both collaboration agreements signed with the prescriptive agreement filed with the state before you prescribe, patient consent documents, including a state-specific telehealth consent, and malpractice insurance in place. Remote collaboration is permitted, so collaborating physicians don't need to be nearby, which widens the search considerably. For malpractice, a number of malpractice groups work with NPs, and Prax can also refer you to different malpractice groups as well.

The Prax Practice Launch Kit handles the full Pennsylvania sequence: entity, governing documents, registered agent, virtual business address, both agreement frameworks, and the complete consent packet.

How long does it take to launch in Pennsylvania?

The entity forms in days to a couple of weeks. The gating item is frequently the physician collaboration and the related state filings. In addition, once you set up your entity, you can start to write off business expenses once it's formed, so it's never too early to get started. Most Pennsylvania CRNPs working with Prax are fully set up within two to three weeks with collaborating agreements moving in parallel. Insurance credentialing adds the usual 90 to 150 days per payer. At Prax, we have contracts set up in PA for all major commercial payors, and generally see providers get in network in about half that time.

Can I run a telehealth practice in Pennsylvania?

Yes. Telehealth-first CRNP practices operate across the state, and remote collaboration rules make the model workable in rural counties. Your agreements need to reflect the virtual model, and your consents need telehealth language, and as always, you can only see patients who are physically in the state you are licensed to see patients in. Given that New Jersey just moved to become a full practice state ("...makes permanent the independent practice authority of certain APNs who provide primary or behavioral health care"), many Philadelphia-area CRNPs are getting licensed and registering their practice entity in New Jersey as well. If this is something you are interested in, feel free to set up a call with the Prax team to strategize.

Quick answers

Do my collaborating physicians own part of my practice in Pennsylvania? No. Collaboration is completely separate from entity ownership. Collaboration relates to clinical requirements to practice independently. If set up correctly, the practice is yours.

Do I really need a substitute physician in Pennsylvania? For prescriptive authority, yes. The filed agreement names at least one substitute alongside your primary collaborator. Please note that many NPs simply work with MDs or DOs that they have worked with previously as their primary and/or substitute collaborator. If you don't have someone in your network, there are also really great groups that specialize in setting up collaborations who we are happy to introduce you to.

Does experience ever end the collaboration requirement? Not under current Pennsylvania law. That said, regulations around NP practice authority are constantly changing, so this could easily change over time.

Can my collaborating physician be far away? Yes. Remote collaboration is permitted in Pennsylvania, just be aware of the availability obligations.

What's the first step? The first step is getting your legal foundation set up, including your legal entity and core agreements. A free call with the Prax team can get you started in Pennsylvania.

This guide is for general information only and isn't legal, tax, or medical advice. Pennsylvania requirements change. Talk with a qualified professional about your situation.

Disclaimer:
The information and/or resources provided in this post and elsewhere on the Prax Health site is provided for general informational purposes only and to assist you as you evaluate engaging in Prax Health's services. It is not intended as, and Prax Health, Inc. does not provide, medical advice, diagnosis or treatment nor is it intended to be legal or tax advice.

Sources

  1. 49 Pa. Code ch. 21, subch. C — Certified Registered Nurse Practitioners (collaborative agreements, prescriptive authority)
  2. Pennsylvania Department of Human Services, Form MA 28 — CRNP Prescriptive Authority Collaborative Agreement
  3. Pennsylvania Department of State — Telemedicine FAQs
  4. New York State Education Department — Nurse Practitioner Practice Requirements
  5. Massachusetts Board of Registration in Nursing — Prescriptive Authority Requirements
  6. State of New Jersey, Office of the Governor — APN independent practice authority, March 30, 2026
  7. IRS Publication 583 — Starting a Business and Keeping Records
  8. Prax Health Research & Editorial Team

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